Sanada Mitsuhiro, Taguchi Akira, Higashi Yukihito, Tsuda Mikio, Kodama Ichiro, Yoshizumi Masao, Ohama Koso
Department of Obstetrics and Gynecology, Sanada Hospital, Graduate School of Biomedical Sciences, Hiroshima University, 3-13-21 Minami-machi, Minami-ku, Hiroshima 734 0007, Japan.
Atherosclerosis. 2004 Oct;176(2):387-92. doi: 10.1016/j.atherosclerosis.2004.05.021.
It is widely believed that the vasculature plays an important role in bone remodeling. We investigated the relationship between forearm endothelial function and bone mass in the lumbar spine in early postmenopausal women without a history of smoking or diabetes mellitus. We studied the forearm resistance artery endothelial function in 110 Japanese women-52 postmenopausal women with normal spinal bone mineral density (BMD), 36 postmenopausal women with osteopenia, and 22 osteoporotic postmenopausal women. Forearm blood flow (FBF) during reactive hyperemia and after sublingual nitroglycerin (NTG) administration was measured by strain-gauge plethysmography. BMD of the lumbar spine (L2-L4) was measured by dual-energy X-ray absorptiometry. After adjustment for age, body mass index, years since the start of menopause, and basal FBF, women with osteoporosis had a lower maximal FBF response to reactive hyperemia (28.4 +/- 3.8 mL/min per 100 mL tissue) than those with normal BMD (39.8 +/- 2.8 mL/min per 100mL tissue) or osteopenia (35.6 +/- 2.5 mL/min per 100mL tissue) (P = 0.029). A significant increase in serum angiotensin-converting enzyme (ACE) activity (P = 0.042) and a significant decrease in the serum concentrations of nitrite/nitrate (P = 0.041) were noted in osteoporotic women compared to women with normal BMD or osteopenia. The present findings suggest that postmenopausal women with low BMD, especially those with osteoporosis, have impaired endothelial function in the forearm resistance arteries.
人们普遍认为，脉管系统在骨重塑中起重要作用。我们调查了无吸烟或糖尿病病史的绝经后早期女性前臂内皮功能与腰椎骨量之间的关系。我们研究了110名日本女性的前臂阻力动脉内皮功能，其中52名绝经后女性腰椎骨矿物质密度（BMD）正常，36名绝经后女性骨量减少，22名绝经后骨质疏松女性。通过应变片体积描记法测量反应性充血期间及舌下含服硝酸甘油（NTG）后的前臂血流量（FBF）。采用双能X线吸收法测量腰椎（L2-L4）的BMD。在调整年龄、体重指数、绝经开始后的年限和基础FBF后，骨质疏松女性对反应性充血的最大FBF反应（每100 mL组织28.4±3.8 mL/min）低于BMD正常的女性（每100mL组织39.8±2.8 mL/min）或骨量减少的女性（每100mL组织35.6±2.5 mL/min）（P = 0.029）。与BMD正常或骨量减少的女性相比，骨质疏松女性血清血管紧张素转换酶（ACE）活性显著升高（P = 0.042），血清亚硝酸盐/硝酸盐浓度显著降低（P = 0.041）。目前的研究结果表明，BMD低的绝经后女性，尤其是骨质疏松女性，前臂阻力动脉的内皮功能受损。
