Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
UO di Medicina Interna, Policlinico "G. Rodolico", Via S. Sofia 78, 95123, Catania, Italy.
Sci Rep. 2020 Nov 10;10(1):19421. doi: 10.1038/s41598-020-76427-1.
Osteoporosis and atherosclerosis are significant public health problems that often coexist, especially in the elderly. Although some studies have reported an age-dependent relationship, others have suggested a causal relationship between osteoporosis and atherosclerosis. The aim of our study was to evaluate the cardiovascular risk in a population of patients with osteoporosis by measuring carotid intima-media thickness (cIMT) and carotid-femoral pulse wave velocity (cf-PWV). A total of 58 patients with osteoporosis and an equal number of healthy control subjects were enrolled. All subjects underwent (1) a bone densitometry examination using dual X-ray absorptiometry, (2) a vascular evaluation for the measurements of cIMT and cf-PWV and (3) a blood sample for the evaluation of lipids and phosphocalcic metabolism. Patients with osteoporosis had a significant increase in cIMT and cf-PWV. There was also a significant inverse correlation between the femoral neck BMD and cf-PWV values. In conclusion, osteoporotic outpatients have earlier vascular ageing, with an increase of arterial stiffness. These data support a possible association between osteoporosis and atherosclerosis independent of age.
骨质疏松症和动脉粥样硬化是两个重大的公共卫生问题，两者常同时存在，尤其在老年人中。虽然一些研究报道了两者与年龄相关，但其他研究提示骨质疏松症与动脉粥样硬化之间存在因果关系。本研究旨在通过测量颈动脉内膜中层厚度（cIMT）和颈动脉-股动脉脉搏波速度（cf-PWV）来评估骨质疏松症患者的心血管风险。共纳入 58 例骨质疏松症患者和 58 例健康对照组。所有受试者均进行了（1）双能 X 线吸收法骨密度检查，（2）cIMT 和 cf-PWV 血管评估，以及（3）血脂和磷钙代谢评估的血液样本采集。骨质疏松症患者的 cIMT 和 cf-PWV 显著增加。股骨颈 BMD 与 cf-PWV 值之间也存在显著的负相关。综上，骨质疏松症门诊患者存在更早的血管老化，动脉僵硬度增加。这些数据支持骨质疏松症与动脉粥样硬化之间存在独立于年龄的可能关联。
