Shamtsyan Mark, Konusova Valentina, Maksimova Yulia, Goloshchev Alexander, Panchenko Andrey, Simbirtsev Andrey, Petrishchev Nikolay, Denisova Nina
Department of Technology of Microbiological Synthesis, St. Petersburg State Institute of Technology (Technical University), 26 Moscovsky Pr., 198013, Russia.
J Biotechnol. 2004 Sep 30;113(1-3):77-83. doi: 10.1016/j.jbiotec.2004.04.034.
Aqueous extracts from fruit bodies and mycelia of various higher Basidiomycetes were studied in search for reliable biological effects. In vitro and in vivo experiments were conducted. The results showed that the aqueous extracts demonstrated various types of marked biological actions: an increased production of reactive oxygen forms by neutrophil cells of human peripheral blood; a significant mitogenic activity in a wide range of concentrations; stimulation on production of inflammatory cytokines interleukine 1-beta and interleukine-8 by peripheral blood cells; a decrease in both average tumor size in mice with transplanted melanoma B16 and a manifestation of tumorous intoxication; and a prolongation in the survival rate of such mice.
研究了各种高等担子菌子实体和菌丝体的水提取物，以寻找可靠的生物学效应。进行了体外和体内实验。结果表明，水提取物表现出各种显著的生物学作用：人外周血中性粒细胞产生活性氧形式增加；在广泛的浓度范围内具有显著的促有丝分裂活性；刺激外周血细胞产生炎性细胞因子白细胞介素1-β和白细胞介素-8；移植黑色素瘤B16的小鼠平均肿瘤大小减小以及肿瘤中毒表现减轻；并且此类小鼠的存活率延长。
