Jabbour H N, Sales K J
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Academic Centre, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK.
Trends Endocrinol Metab. 2004 Oct;15(8):398-404. doi: 10.1016/j.tem.2004.08.006.
Prostaglandins are bioactive lipids that exert an autocrine or paracrine function by binding to specific G-protein-coupled receptors (GPCRs) to activate intracellular signalling and gene transcription. Prostaglandins are key regulators of reproductive processes, including ovulation, implantation and menstruation. Prostaglandins have been ascertained to have a role in various pathological changes of the reproductive tract including menorrhagia, dysmenorrhea, endometriosis and cancer. Although the mechanism by which prostaglandins modulate these changes remains unclear, much evidence suggests that prostaglandins and their receptors and downstream signalling pathways are involved in angiogenesis and in alterations in cell adhesion, morphology, motility, invasion and metastases. The potential role of prostaglandin receptors in pathological changes of the endometrium has significance for the future development of therapeutic interventions.
前列腺素是具有生物活性的脂质，通过与特定的G蛋白偶联受体（GPCRs）结合来发挥自分泌或旁分泌功能，从而激活细胞内信号传导和基因转录。前列腺素是生殖过程的关键调节因子，包括排卵、着床和月经。已确定前列腺素在生殖道的各种病理变化中起作用，包括月经过多、痛经、子宫内膜异位症和癌症。尽管前列腺素调节这些变化的机制尚不清楚，但大量证据表明，前列腺素及其受体和下游信号通路参与血管生成以及细胞黏附、形态、运动、侵袭和转移的改变。前列腺素受体在子宫内膜病理变化中的潜在作用对治疗干预的未来发展具有重要意义。
