The Hormel Institute, University of Minnesota, Austin, Minnesota.
Cancer Res. 2022 Mar 15;82(6):949-965. doi: 10.1158/0008-5472.CAN-21-2297.
Because of profound effects observed in carcinogenesis, prostaglandins (PG), prostaglandin-endoperoxide synthases, and PG receptors are implicated in cancer development and progression. Understanding the molecular mechanisms of PG actions has potential clinical relevance for cancer prevention and therapy. This review focuses on the current status of PG signaling pathways in modulating cancer progression and aims to provide insights into the mechanistic actions of PGs and their receptors in influencing tumor progression. We also examine several small molecules identified as having anticancer activity that target prostaglandin receptors. The literature suggests that targeting PG pathways could provide opportunities for cancer prevention and therapy.
由于在致癌作用中观察到的深远影响，前列腺素（PG）、前列腺素内过氧化物合酶和 PG 受体被牵涉到癌症的发展和进展中。了解 PG 作用的分子机制对于癌症的预防和治疗具有潜在的临床相关性。这篇综述集中在调节癌症进展的 PG 信号通路的现状上，旨在提供对 PG 及其受体影响肿瘤进展的机制作用的深入了解。我们还研究了几种被确定为具有抗癌活性的小分子，这些小分子以前列腺素受体为靶点。文献表明，靶向 PG 途径可能为癌症的预防和治疗提供机会。
