为什么是钙刺激型腺苷酸环化酶？
Why calcium-stimulated adenylyl cyclases?
作者信息
Ferguson Gregory D, Storm Daniel R
机构信息
Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.
出版信息
Physiology (Bethesda). 2004 Oct;19:271-6. doi: 10.1152/physiol.00010.2004.
PMID:15381755
Abstract
The Ca(2+)/calmodulin-stimulated adenylyl cyclases, AC1 and AC8, play a critical role in several forms of neuroplasticity, including long-lasting long-term potentiation (L-LTP) and long-term memory (LTM). By coupling neuronal activity and Ca(2+) increases to the production of cAMP, AC1 and AC8 activate cAMP-dependent signal transduction and transcriptional pathways critical for L-LTP and LTM.
摘要
钙（Ca2+）/钙调蛋白刺激的腺苷酸环化酶AC1和AC8在多种神经可塑性形式中发挥关键作用，包括持久的长时程增强（L-LTP）和长期记忆（LTM）。通过将神经元活动和Ca2+增加与cAMP的产生相偶联，AC1和AC8激活对L-LTP和LTM至关重要的cAMP依赖性信号转导和转录途径。
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