腺苷酸环化酶与环磷酸腺苷的调控及组织
Regulation and organization of adenylyl cyclases and cAMP.
作者信息
Cooper Dermot M F
机构信息
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.
出版信息
Biochem J. 2003 Nov 1;375(Pt 3):517-29. doi: 10.1042/BJ20031061.
Abstract
Adenylyl cyclases are a critically important family of multiply regulated signalling molecules. Their susceptibility to many modes of regulation allows them to integrate the activities of a variety of signalling pathways. However, this property brings with it the problem of imparting specificity and discrimination. Recent studies are revealing the range of strategies utilized by the cyclases to solve this problem. Microdomains are a consequence of these solutions, in which cAMP dynamics may differ from the broad cytosol. Currently evolving methodologies are beginning to reveal cAMP fluctuations in these various compartments.
摘要
腺苷酸环化酶是一类受到多重调节的极其重要的信号分子家族。它们对多种调节模式的敏感性使它们能够整合各种信号通路的活性。然而，这一特性也带来了赋予特异性和区分性的问题。最近的研究正在揭示环化酶用来解决这一问题的一系列策略。微区是这些解决方案的结果，其中环磷酸腺苷（cAMP）的动态变化可能与广阔的细胞质不同。目前不断发展的方法开始揭示这些不同区室中环磷酸腺苷的波动情况。
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