Liauw Jason, Wu Long-Jun, Zhuo Min
Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Bldg., Rm. 3342, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
J Neurophysiol. 2005 Jul;94(1):878-82. doi: 10.1152/jn.01205.2004.
Activity-dependent long-term potentiation (LTP) in the CNS is thought to be important in learning, memory, development, and persistent pain. Here, we report that NMDA receptor-dependent LTP is the major form of long-term plasticity in the anterior cingulate cortex (ACC). In addition to N-methyl-D-aspartate (NMDA) receptors, L-type voltage-gated calcium channels are also required for inducing LTP. Activation of calcium-stimulated adenylyl cyclase subtype 1 (AC1) is essential for the induction of LTP in ACC neurons, while AC8 subunit partially contributes to forskolin-induced potentiation. Our results suggest that calcium-stimulated cAMP-dependent signaling pathways play a critical role in cingulate LTP.
中枢神经系统中依赖活动的长时程增强（LTP）被认为在学习、记忆、发育和持续性疼痛中起重要作用。在此，我们报告NMDA受体依赖性LTP是前扣带回皮质（ACC）中长时可塑性的主要形式。除N-甲基-D-天冬氨酸（NMDA）受体外，L型电压门控钙通道对于诱导LTP也是必需的。钙刺激的腺苷酸环化酶1型（AC1）的激活对于ACC神经元中LTP的诱导至关重要，而AC8亚基对福斯高林诱导的增强作用有部分贡献。我们的结果表明，钙刺激的cAMP依赖性信号通路在扣带回LTP中起关键作用。
