Suppr超能文献

一个多民族大城市中青少年2型糖尿病的临床表现及病程

Presentation and course of Type 2 diabetes in youth in a large multi-ethnic city.

作者信息

Zdravkovic V, Daneman D, Hamilton J

机构信息

Hospital for Sick Children, Toronto, Ontario, Canada.

出版信息

Diabet Med. 2004 Oct;21(10):1144-8. doi: 10.1111/j.1464-5491.2004.01297.x.

Abstract

AIM

To review the clinical experience of children and teens diagnosed with Type 2 diabetes (T2DM) at a paediatric hospital serving a large urban multi-ethnic population.

METHODS

Retrospective chart review of patients with T2DM followed in the diabetes clinic at the Hospital for Sick Children (HSC) over an 8-year period. Patients who were included were younger than 18, referred at the onset of diabetes, and where presentation and/or clinical course was 'typical' of T2DM.

RESULTS

Of 1020 children with diabetes followed at HSC, 4% were identified as having T2DM in 2002. There was a sixfold increase in new cases from 1994 to 2002. The mean age at diagnosis was 13.5 +/- 2.2 years (range 8.8-17.5) with a female-to-male ratio of 1.7. Most had a first- or second-degree relative with T2DM. There was an overrepresentation of children with T2DM from Asian and African Canadian ethnic groups relative to the regional population. The majority of teens were asymptomatic at presentation, with a smaller number in diabetic ketoacidosis (DKA) at diagnosis. Mean HbA1c at diagnosis was 10 +/- 3.4%. Approximately one half of patients were initially treated by diet and exercise with many requiring intensification of therapy over a short period of time.

CONCLUSIONS

We report a similar increase in T2DM incidence and clinical presentation at HSC to other clinic reports in large North American urban centres. Of note is the high prevalence of children of South/South-East Asian descent.

摘要

目的

回顾在一家为城市多民族人口提供服务的儿科医院中,诊断为2型糖尿病(T2DM)的儿童和青少年的临床经验。

方法

对在病童医院(HSC)糖尿病门诊随访8年的T2DM患者进行回顾性病历审查。纳入的患者年龄小于18岁,在糖尿病发病时就诊,且其临床表现和/或临床病程具有T2DM的“典型特征”。

结果

在HSC随访的1020例糖尿病儿童中,2002年有4%被确诊为T2DM。从1994年到2002年,新病例增加了6倍。诊断时的平均年龄为13.5±2.2岁(范围8.8 - 17.5岁),女性与男性的比例为1.7。大多数患者有T2DM的一级或二级亲属。与该地区人口相比,来自亚洲和加拿大非洲裔族群的T2DM儿童比例过高。大多数青少年就诊时无症状,诊断时较少有糖尿病酮症酸中毒(DKA)。诊断时的平均糖化血红蛋白(HbA1c)为10±3.4%。约一半患者最初通过饮食和运动治疗,许多患者在短时间内需要强化治疗。

结论

我们报告HSC的T2DM发病率和临床表现与北美大型城市中心的其他临床报告相似。值得注意的是,南亚/东南亚裔儿童的患病率很高。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验