NIHR Biomedical Research Centre: Nutrition, Diet and Lifestyle Theme, School of Oral and Dental Sciences, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Diabet Med. 2018 Jun;35(6):737-744. doi: 10.1111/dme.13609. Epub 2018 Mar 24.
To estimate the incidence of Type 2 diabetes in children aged <17 years, compare this with similar data 10 years ago, and characterize clinical features at diagnosis in the UK and Republic of Ireland.
Using the British Paediatric Surveillance Unit reporting framework, cases of Type 2 diabetes diagnosed in children aged <17 years between 1 April 2015 and 30 April 2016 were reported each month.
A total of 106 cases were reported, giving a UK incidence of 0.72/100 000 (95% CI 0.58-0.88). Children from ethnic minorities had significantly higher incidence compared with white children (0.44/100 000) with rates of 2.92/100 000 and 1.67/100 000, in Asian and BACBB (black/African/Caribbean/black British) children respectively. Sixty-seven percent were girls and 81% had a family history of Type 2 diabetes. The mean BMI sd score at diagnosis was 2.89 (2.88, girls; 2.92, boys); 81% were obese. Children of Asian ethnicity had a significantly lower BMI sd score compared with white children (P<0.001). There was a trend in increased incidence from 2005 to 2015, with a rate ratio of 1.35 (95% CI 0.99-1.84), although this was not statistically significant (P=0.062). There was statistical evidence of increased incidence among girls (P=0.03) and children of South-Asian ethnicity (P=0.01) when comparing the 2005 and 2015 surveys.
Type 2 diabetes remains far less common than Type 1 diabetes in childhood in the UK, but the number of cases continues to rise, with significantly increased incidence among girls and South-Asian children over a decade. Female gender, family history, non-white ethnicity and obesity were found to be strongly associated with the condition.
估计年龄<17 岁的儿童 2 型糖尿病的发病率，将其与 10 年前的类似数据进行比较，并描述英国和爱尔兰共和国的诊断时临床特征。
使用英国儿科监测单位报告框架，每月报告 2015 年 4 月 1 日至 2016 年 4 月 30 日期间年龄<17 岁的儿童中诊断为 2 型糖尿病的病例。
共报告了 106 例病例，英国的发病率为 0.72/100 000（95%CI 0.58-0.88）。与白人儿童（0.44/100 000）相比，少数民族儿童的发病率明显更高，亚洲儿童为 2.92/100 000，黑人/非裔/加勒比/黑人英国儿童为 1.67/100 000。67%为女孩，81%有 2 型糖尿病家族史。诊断时平均 BMI sd 评分（女孩为 2.89，男孩为 2.92）为 2.89；81%为肥胖。亚洲儿童的 BMI sd 评分明显低于白人儿童（P<0.001）。2005 年至 2015 年期间，发病率呈上升趋势，比率为 1.35（95%CI 0.99-1.84），但无统计学意义（P=0.062）。与 2005 年相比，2015 年的调查显示，女孩（P=0.03）和南亚裔儿童（P=0.01）的发病率有统计学意义的增加。
英国儿童 2 型糖尿病的发病率仍远低于 1 型糖尿病，但病例数量仍在持续增加，女孩和南亚裔儿童的发病率显著增加。女性、家族史、非白人种族和肥胖与该疾病密切相关。
