在冈比亚进行的一项横断面调查中，19千道尔顿裂殖子表面蛋白1特异性抗体的精细特异性而非入侵抑制活性与对疟疾寄生虫血症的抗性相关。
The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia.
作者信息
Corran Patrick H, O'Donnell Rebecca A, Todd Jim, Uthaipibull Chairat, Holder Anthony A, Crabb Brendan S, Riley Eleanor M
机构信息
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
出版信息
Infect Immun. 2004 Oct;72(10):6185-9. doi: 10.1128/IAI.72.10.6185-6189.2004.
Abstract
In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-1(19))-specific erythrocyte invasion inhibitory activity of antibodies to MSP-1(19) but find no significant association between any of these parameters and prevalence or density of malarial parasitemia, except that, after correcting for total anti-MSP-1(19) antibody levels, individuals with anti-MSP-1(19) antibodies that compete with an invasion inhibitory monoclonal antibody (12.10) were significantly less likely to have malaria infections with densities of > or =1,000 parasites/microl than were individuals without such antibodies. This association persisted after correction for age and ethnic origin.
摘要
在一项针对187名冈比亚儿童和成人的横断面调查中，我们分析了针对19千道尔顿裂殖子表面蛋白1（MSP-1(19)）的抗体的流行率、精细特异性以及MSP-1(19)特异性红细胞入侵抑制活性，但发现这些参数中的任何一个与疟疾寄生虫血症的流行率或密度之间均无显著关联，不过，在校正总抗MSP-1(19)抗体水平后，与一种入侵抑制性单克隆抗体（12.10）竞争的抗MSP-1(19)抗体个体感染密度≥1000个寄生虫/微升的疟疾的可能性显著低于没有此类抗体的个体。在校正年龄和种族后，这种关联仍然存在。
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