杠柳中脂氧合酶抑制成分。

Lipoxygenase inhibitory constituents from Periploca aphylla.

作者信息

Aziz-Ur-Rehman Aziz-Ur-Rehman, Malik Abdul, Riaz Naheed, Nawaz Hafiz Rub, Ahmad Habib, Nawaz Sarfraz Ahmad, Choudhary M Iqbal

机构信息

International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.

出版信息

J Nat Prod. 2004 Sep;67(9):1450-4. doi: 10.1021/np030494o.

DOI:10.1021/np030494o

PMID:15387640

Abstract

Bisflavan-3-ols 1 and 2 and norterpenoid 3 have been isolated from the methanolic extract of the whole plant of Periploca aphylla. Their structures have been assigned on the basis of spectroscopic analysis including 1D and 2D NMR techniques. In addition, o-phthalic acid bis(2-ethylnonyl) ester (4), 1,3,6-trihydroxy-2,5-dimethoxyxanthone (5), and (+)-lyoniresinol (6) have been reported for the first time from this species. Compounds 1-3 displayed evident inhibitory potential against the enzyme lipoxygenase in a concentration-dependent fashion with IC(50) values 19.7, 13.5, and 150.1 microM, respectively.

摘要

双黄酮-3-醇1和2以及降萜类化合物3是从无叶杠柳全株的甲醇提取物中分离得到的。它们的结构是通过包括一维和二维核磁共振技术在内的光谱分析确定的。此外，邻苯二甲酸双（2-乙基壬基）酯（4）、1,3,6-三羟基-2,5-二甲氧基呫吨酮（5）和（+）-裂环异落叶松脂醇（6）首次从该物种中被报道。化合物1-3对脂氧合酶显示出明显的抑制潜力，呈浓度依赖性，IC（50）值分别为19.7、13.5和150.1微摩尔。