Sulston J, Du Z, Thomas K, Wilson R, Hillier L, Staden R, Halloran N, Green P, Thierry-Mieg J, Qiu L
MRC Laboratory of Molecular Biology, Cambridge, UK.
Nature. 1992 Mar 5;356(6364):37-41. doi: 10.1038/356037a0.
The long-term goal of this project is the elucidation of the complete sequence of the Caenorhabditis elegans genome. During the first year methods have been developed and a strategy implemented that is amenable to large-scale sequencing. The three cosmids sequenced in this initial phase are surprisingly rich in genes, many of which have mammalian homologues.
该项目的长期目标是阐明秀丽隐杆线虫基因组的完整序列。在第一年里,已经开发出了方法并实施了一种适用于大规模测序的策略。在这个初始阶段测序的三个黏粒惊人地富含基因,其中许多基因有哺乳动物的同源物。