Yasuda Kayo, Miyazawa Masaki, Ishii Takamasa, Ishii Naoaki
Department of Health Management, Undergraduate School of Health Studies, Tokai University, 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan.
Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
J Clin Biochem Nutr. 2023 Nov;73(3):173-177. doi: 10.3164/jcbn.23-44. Epub 2023 Jul 6.
The molecular mechanism of aging, which has been a "black box" for many years, has been elucidated in recent years, and the nematode , which is a model animal for aging research, has played a major role in its elucidation. From the analysis of longevity-related mutant genes, many signal transduction systems, with the insulin/insulin-like growth factor signal transduction system at the core, have emerged. It has become clear that this signal transduction system is greatly affected by external nutrients and is involved in the downstream regulation of oxidative stress, which is considered to be one of the main causes of aging.
衰老的分子机制多年来一直是个“黑匣子”，近年来已被阐明，而作为衰老研究模式动物的线虫在这一阐明过程中发挥了重要作用。通过对与长寿相关的突变基因进行分析，出现了许多信号转导系统，其中以胰岛素/胰岛素样生长因子信号转导系统为核心。已经明确，该信号转导系统受到外部营养物质的极大影响，并参与氧化应激的下游调节，氧化应激被认为是衰老的主要原因之一。
