Poupot Mary, Fournié Jean-Jacques
département Oncogénèse and Signalisation dans les Cellules Hématopoiétiques, Unité 563 de l'Institut National de la Santé Et de la Recherche Médicale, Centre de Physiopathologie de Toulouse Purpan, BP3028, 31024 Toulouse, France.
Immunol Lett. 2004 Sep;95(2):129-38. doi: 10.1016/j.imlet.2004.06.013.
Various non-peptidic ligands which specifically activate most of circulating human Vgamma9/Vdelta2 T lymphocytes are now known. Most of these are so-called phosphoantigens and directly trigger the Vgamma9/Vdelta2 TCR expressing cells, without need for MHC-restricted presentation molecules. Although some potent phosphoantigens currently involved in clinical trials are chemically-synthesized molecules, most of the natural antigens were isolated from microbial cultures. The structures and biosynthesis of phosphoantigens are reviewed here and the possible physiological significance of their recognition by gammadelta T lymphocytes is discussed.
现已发现多种能特异性激活大多数循环人Vγ9/Vδ2 T淋巴细胞的非肽类配体。其中大多数是所谓的磷酸抗抗原，可直接触发表达Vγ9/Vδ2 TCR的细胞，无需MHC限制性呈递分子。尽管目前一些参与临床试验的强效磷酸抗抗原是化学合成分子，但大多数天然抗原是从微生物培养物中分离出来的。本文综述了磷酸抗抗原的结构和生物合成，并讨论了γδ T淋巴细胞识别它们的可能生理意义。
