CARB-9是一种编码在霍乱弧菌非O1、非O139型VCR区域的羧苄青霉素酶，属于盒式编码β-内酰胺酶家族。
CARB-9, a carbenicillinase encoded in the VCR region of Vibrio cholerae non-O1, non-O139 belongs to a family of cassette-encoded beta-lactamases.
作者信息
Petroni Alejandro, Melano Roberto G, Saka Héctor A, Garutti Alicia, Mange Laura, Pasterán Fernando, Rapoport Melina, Miranda Mariana, Faccone Diego, Rossi Alicia, Hoffman Paul S, Galas Marcelo F
机构信息
Servicio Antimicrobianos, INEI-ANLIS "Dr. Carlos G. Malbrán," Av. Velez Sarsfield 563 (1281), Buenos Aires, Argentina.
出版信息
Antimicrob Agents Chemother. 2004 Oct;48(10):4042-6. doi: 10.1128/AAC.48.10.4042-4046.2004.
Abstract
The gene bla(CARB-9) was located in the Vibrio cholerae super-integron, but in a different location relative to bla(CARB-7). CARB-9 (pI 5.2) conferred beta-lactam MICs four to eight times lower than those conferred by CARB-7, differing at Ambler's positions V97I, L124F, and T228K. Comparison of the genetic environments of all reported bla(CARB) genes indicated that the CARB enzymes constitute a family of cassette-encoded beta-lactamases.
摘要
bla（CARB-9）基因位于霍乱弧菌超级整合子中，但相对于bla（CARB-7）处于不同位置。CARB-9（pI 5.2）赋予的β-内酰胺最低抑菌浓度比CARB-7赋予的低4至8倍，在安布勒位置V97I、L124F和T228K处存在差异。对所有已报道的bla（CARB）基因的遗传环境进行比较表明，CARB酶构成了一个盒式编码β-内酰胺酶家族。
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