脱氧胸苷寡核苷酸的益生元合成。II. 缩合剂的比较。
The prebiotic synthesis of deoxthymidine oligonucleotides. II. Comparison of condensing agents.
作者信息
Odom D G, Brady J T
出版信息
J Mol Evol. 1975 Nov 4;6(3):199-207. doi: 10.1007/BF01732356.
PMID:1540
Abstract
A reaction which oligomerizes nucleotides under possible prebiotic conditions has been characterized. Nucleoside monophosphate in the presence of cyanamide at acid pH condenses to form dithymideine pyrophosphate and phosphodiester bonded compounds. Imidazole compounds and activated precursors such as nucleoside triphosphate are not necessary for this ologomerization reaction which produces primarily cyclic ologonucleotides.
摘要
一种在可能的益生元条件下使核苷酸寡聚化的反应已得到表征。在酸性pH条件下，单磷酸核苷在氰胺存在下缩合形成焦磷酸双胸苷和磷酸二酯键合化合物。对于这种主要产生环状寡核苷酸的寡聚化反应，咪唑化合物和诸如三磷酸核苷等活化前体并非必需。
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