Fenoglio-Preiser C M
Department of Pathology, University of Cincinnati, Ohio 45267-0529.
Cancer. 1992 Mar 15;69(6 Suppl):1607-32. doi: 10.1002/1097-0142(19920315)69:6+<1607::aid-cncr2820691317>3.0.co;2-c.
In this article, the use of cellular and molecular markers to diagnose and stage tumors is discussed. Their role in the evaluation of tumor prognosis and tumor susceptibility also is covered. The immunologic, cytogenetic, and molecular phenotype is discussed. Traditional markers are compared with newer methodologic approaches including evaluation of oncogenes, tumor suppressor genes, and genes that predict tumor susceptibility. These discussions are presented in relation to specific tumors. Finally, statements one might use to decide which tests to perform are presented.
本文讨论了使用细胞和分子标志物来诊断肿瘤及确定肿瘤分期。还涵盖了它们在评估肿瘤预后和肿瘤易感性方面的作用。文中讨论了免疫、细胞遗传学和分子表型。将传统标志物与包括癌基因、肿瘤抑制基因及预测肿瘤易感性基因评估在内的更新的方法学途径进行了比较。这些讨论是针对特定肿瘤展开的。最后，给出了用于决定进行哪些检测的相关陈述。
