Korf Bruce, M Mikhail Fady
University of Alabama at Birmingham, Birmingham, Alabama, USA.
Curr Protoc Hum Genet. 2007 Oct;Chapter 10:Unit 10.1. doi: 10.1002/0471142905.hg1001s55.
Both cytogenetic and molecular genetic studies can contribute to the management of patients with cancer. In some cases genetic markers are specific to particular tumor types and are useful in diagnosis. This can be helpful in distinguishing histologically similar tumors that may respond differently to treatment and can sometimes be of prognostic value. Genetic markers can also be tools for following the response of a tumor to therapy, providing a sensitive means of detection of relapse. This introductory unit considers some of the types of genetic changes that occur in association with malignancies and major approaches used in their detection.
细胞遗传学和分子遗传学研究都有助于癌症患者的管理。在某些情况下，基因标志物对特定肿瘤类型具有特异性，对诊断很有用。这有助于区分组织学上相似但对治疗反应可能不同的肿瘤，有时还具有预后价值。基因标志物也可作为跟踪肿瘤对治疗反应的工具，提供一种检测复发的敏感方法。本入门单元将探讨一些与恶性肿瘤相关的基因变化类型及其检测的主要方法。
