Bollag W, Peck R, Frey J R
Pharmaceutical Research, F. Hoffmann-La Roche Ltd., Basle, Switzerland.
Cancer Lett. 1992 Feb 29;62(2):167-72. doi: 10.1016/0304-3835(92)90188-2.
Various combinations of retinoids and cytokines were examined for their synergistic effect on inhibition in proliferation of four human transformed epithelial cell lines, MCF7 (mammary carcinoma), SCC4, SCC15 and A431 (squamous cell carcinomas). Synergism depended on the cell line tested, to some degree on the specific retinoid but particularly on the type of cytokine used. IFN alpha had the widest spectrum of activity. IFN gamma, TNF-alpha, IL-1, EGF and TGF-beta also exerted a synergistic effect on proliferation inhibition in certain cell lines, whereas G-CSF was inactive. Association of retinoids and cytokines represents a new approach to antitumor chemotherapy.
研究了视黄酸和细胞因子的各种组合对四种人转化上皮细胞系（MCF7（乳腺癌）、SCC4、SCC15和A431（鳞状细胞癌））增殖抑制的协同作用。协同作用在一定程度上取决于所测试的细胞系，部分取决于特定的视黄酸，但尤其取决于所使用的细胞因子类型。α干扰素具有最广泛的活性谱。γ干扰素、肿瘤坏死因子-α、白细胞介素-1、表皮生长因子和转化生长因子-β在某些细胞系中也对增殖抑制发挥协同作用，而粒细胞集落刺激因子则无活性。视黄酸与细胞因子的联合代表了一种抗肿瘤化疗的新方法。
