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维甲酸、α干扰素及其联合应用对五种人转化细胞系的抗增殖活性

Antiproliferative activity of retinoids, interferon alpha and their combination in five human transformed cell lines.

作者信息

Frey J R, Peck R, Bollag W

机构信息

Pharmaceutical Research, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

出版信息

Cancer Lett. 1991 May 24;57(3):223-7. doi: 10.1016/0304-3835(91)90161-a.

DOI:10.1016/0304-3835(91)90161-a
PMID:1827753
Abstract

Tretinoin, isotretinoin and acitretin were examined for their capacity to modulate the proliferation of the cell lines: HL-60 (acute promyelocytic leukemia), MCF7 (mammary carcinoma), SCC4, SCC15 and A431 (squamous cell carcinomas). Retinoids inhibited proliferation to a varying extent in all 5 cell lines. The cytokine IFN alpha had a significant antiproliferative effect only on HL-60, SCC4 and SCC15. The combination of retinoids with IFN alpha led in all 5 cell lines to a more profound reduction in proliferation than either retinoids or IFN alpha alone.

摘要

研究了维甲酸、异维甲酸和阿维A调节以下细胞系增殖的能力：HL-60（急性早幼粒细胞白血病）、MCF7（乳腺癌）、SCC4、SCC15和A431（鳞状细胞癌）。维甲酸在所有5种细胞系中均不同程度地抑制了增殖。细胞因子IFNα仅对HL-60、SCC4和SCC15具有显著的抗增殖作用。维甲酸与IFNα联合使用在所有5种细胞系中导致的增殖减少比单独使用维甲酸或IFNα更为显著。

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