McGeown M G, Nevin N C
Proc Eur Dial Transplant Assoc. 1978;15:384-90.
Two women previously treated with cyclophosphamide had five pregnancies, resulting in seven normal offspring, including two sets of twins. All the babies had normal chromosome constitution and there was no significant chromosome damage. Apart from the twin pregnancies, which were induced, the pregnancies continued to full term and the birth weights were good. Men with renal transplants receiving azathioprine and prednisolone fathered 13 pregnancies, resulting in 11 offspring; one was a mongol; there were two spontaneous abortions, including a twin pregnancy. With the exception of the mongol, the babies had normal chromosome constitution and there was no significant chromosome damage. Two women with renal transplants receiving azathioprine and prednisolone have had four pregnancies, two ended in spontaneous abortion and two continue.
两名曾接受环磷酰胺治疗的女性怀孕五次，产下七名正常后代，其中包括两对双胞胎。所有婴儿的染色体构成均正常，且无明显染色体损伤。除了人工诱导的双胞胎妊娠外，其他妊娠均足月分娩，出生体重正常。接受硫唑嘌呤和泼尼松龙治疗的肾移植男性使13名女性怀孕，产下11名后代；其中一名是先天愚型儿；有两次自然流产，包括一次双胞胎妊娠。除先天愚型儿外，其他婴儿的染色体构成均正常，且无明显染色体损伤。两名接受硫唑嘌呤和泼尼松龙治疗的肾移植女性怀孕四次，两次自然流产，两次妊娠仍在继续。
