Bosso J V, Creighton D, Stevenson D D
Department of Molecular and Experimental Medicine, Scripps Clinic and Research Foundation, La Jolla, Cal.
Chest. 1992 Mar;101(3):856-8. doi: 10.1378/chest.101.3.856.
Flurbiprofen (Ansaid) is a newly released nonsteroidal antiinflammatory drug (NSAID) that is a potent inhibitor of prostaglandin synthesis. We report the first case (to our knowledge) of a flurbiprofen-induced asthmatic reaction confirmed by single-blind oral challenges. Cross-sensitivity and cross-desensitization between aspirin (ASA) and flurbiprofen were also demonstrated in this patient with rhinosinusitis and asthma, thus reinforcing the observation that NSAIDs capable of cyclooxygenase inhibition crossreact with ASA in producing characteristic respiratory reactions.
氟比洛芬（安赛德）是一种新上市的非甾体抗炎药（NSAID），是前列腺素合成的强效抑制剂。据我们所知，我们报告了首例经单盲口服激发试验确诊的氟比洛芬诱发的哮喘反应病例。该患有鼻窦炎和哮喘的患者还表现出阿司匹林（ASA）与氟比洛芬之间的交叉敏感性和交叉脱敏反应，从而进一步证实了以下观察结果：能够抑制环氧化酶的非甾体抗炎药在产生特征性呼吸道反应方面与ASA存在交叉反应。
