Gandevia S C, Ammon K
Department of Clinical Neurophysiology, Prince of Wales Medical Research, University of New South Wales, Sydney, Australia.
Exp Brain Res. 1992;88(1):219-23. doi: 10.1007/BF02259145.
The present study determined whether the cortical potential from the human index finger changed with chronic nerve stimulation. Cerebral potentials were repeatedly recorded to stimulation of the ulnar nerve and the digital nerves of thumb, index and middle fingers, before and during a 7-day period in which the index was electrically stimulated (80 Hz) for 8-10 h daily. Cerebral potentials were recorded at three scalp sites over the contralateral "hand" area. Chronic stimulation produced no significant changes in the amplitudes or distribution of the cerebral potentials from the individual digits or the ulnar nerve. However, for the stimulated index finger there was a significant, progressive increase in latency of N20 and P25 without a detectable change in conduction velocity of distal peripheral axons. Timing in human central somatosensory pathways may be altered by the previous pattern of peripheral nerve inputs.
本研究确定了人类食指的皮层电位是否会随着慢性神经刺激而改变。在对食指进行为期7天、每天8 - 10小时的电刺激（80赫兹）之前和期间，反复记录对尺神经以及拇指、食指和中指的指神经进行刺激时的脑电位。在对侧“手部”区域的三个头皮部位记录脑电位。慢性刺激并未使来自各个手指或尺神经的脑电位的幅度或分布产生显著变化。然而，对于受刺激的食指，N20和P25的潜伏期有显著的渐进性增加，而远端外周轴突的传导速度没有可检测到的变化。人类中枢体感通路的时间可能会因先前的外周神经输入模式而改变。
