食管失弛缓症患者食管、胃、空肠和结肠的奥尔巴赫神经丛组织学研究：与胃酸分泌、壁细胞存在及固体食物胃排空的相关性
Histological studies of Auerbach's plexuses of the oesophagus, stomach, jejunum, and colon in patients with achalasia of the oesophagus: correlation with gastric acid secretion, presence of parietal cells and gastric emptying of solids.
作者信息
Csendes A, Smok G, Braghetto I, González P, Henríquez A, Csendes P, Pizurno D
机构信息
Department of Surgery, Pathology and Nuclear Medicine, University Hospital, University of Chile, Santiago.
出版信息
Gut. 1992 Feb;33(2):150-4. doi: 10.1136/gut.33.2.150.
Histological changes in the Auerbach's plexuses of the oesophagus, stomach, jejunum, and colon were analysed in a prospective study in 34 patients with achalasia of the oesophagus. At the distal end of the oesophagus ganglia cells were absent in 91% of cases as well as in the middle third of the stomach (20%). The Auerbach's plexuses were normal in the jejunum and colon. The results of gastric acid secretion showed that the peak acid output was significantly lower in achalasia patients compared with controls (p less than 0.001). There was no correlation between the mean ganglion neuronal count in the gastric plexuses and the rate of gastric acid output (r = 0.33). Gastric emptying of solids was also evaluated, but there was no correlation between gastric emptying and the mean ganglion neuronal count in the gastric Auerbach's plexuses. The rate of gastric emptying of solids was similar in controls and patients with achalasia. These studies suggest that denervation of the oesophagus in patients with achalasia, which is a constant finding in several previous reports may extend beyond the oesophagus to the stomach in nearly half the cases.
在一项针对34例贲门失弛缓症患者的前瞻性研究中，分析了食管、胃、空肠和结肠的奥尔巴赫神经丛的组织学变化。在食管远端，91%的病例以及胃中三分之一处（20%）的神经节细胞缺失。空肠和结肠的奥尔巴赫神经丛正常。胃酸分泌结果显示，与对照组相比，贲门失弛缓症患者的胃酸分泌峰值显著降低（p<0.001）。胃神经丛中神经节神经元平均计数与胃酸分泌率之间无相关性（r=0.33）。还评估了固体食物的胃排空情况，但胃排空与胃奥尔巴赫神经丛中神经节神经元平均计数之间无相关性。对照组和贲门失弛缓症患者的固体食物胃排空率相似。这些研究表明，贲门失弛缓症患者食管去神经支配在之前的几份报告中是一个常见发现，在近一半的病例中可能不仅局限于食管，还会延伸至胃。
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