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Pregnenolone.

作者信息

HENDERSON E, WEINBERG M, WRIGHT W A

出版信息

J Clin Endocrinol Metab. 1950 Apr;10(4):455-74. doi: 10.1210/jcem-10-4-455.

DOI:10.1210/jcem-10-4-455
PMID:15415436
Abstract
摘要

相似文献

1
Pregnenolone.孕烯醇酮
J Clin Endocrinol Metab. 1950 Apr;10(4):455-74. doi: 10.1210/jcem-10-4-455.
2
Pregnenolone Preliminary report on pregnenolone acetate and acetoxypregnenolone in arthritis and soft tissue rheumatism.孕烯醇酮 关于醋酸孕烯醇酮和乙酰氧基孕烯醇酮治疗关节炎和软组织风湿病的初步报告。
N Y State J Med. 1951 May 1;51(9):1167-70.
3
[THE BIOSYNTHESIS OF 17-HYDROXY- AND 17-DESOXYCORTICOSTEROIDS BY SWINE ADRENAL CORTEX HOMOGENATES FROM PROGESTERONE-4-C14, PREGNENOLONE-21-C14 AND PREGNENOLONE-4-C14].[猪肾上腺皮质匀浆利用孕酮 - 4 - C¹⁴、孕烯醇酮 - 21 - C¹⁴和孕烯醇酮 - 4 - C¹⁴合成17 - 羟基和17 - 去氧皮质类固醇]
Biokhimiia. 1964 Jul-Aug;29:707-15.
4
Synthesis of [3α-(3) H] 17α-hydroxy pregnenolone and [3α-(3) H] pregnenolone.[3α-(3)H]17α-羟基孕烯醇酮和[3α-(3)H]孕烯醇酮的合成
J Labelled Comp Radiopharm. 2014 Jan;57(1):1-11. doi: 10.1002/jlcr.3114. Epub 2013 Oct 24.
5
Pregnenolone-binding proteins in the rat adrenal cortex.大鼠肾上腺皮质中的孕烯醇酮结合蛋白。
Endocrinology. 1977 Oct;101(4):1318-24. doi: 10.1210/endo-101-4-1318.
6
Adrenocortical pregnenolone binding activity resides with estrogen sulfotransferase.肾上腺皮质孕烯醇酮结合活性与雌激素磺基转移酶有关。
Endocrinology. 1995 Jan;136(1):361-4. doi: 10.1210/endo.136.1.7828553.
7
A neuroactive steroid, pregnenolone, alters the striatal dopaminergic tone before and after puberty.一种神经活性甾体化合物孕烯醇酮，会在青春期前后改变纹状体多巴胺能张力。
Neuroendocrinology. 2002 May;75(5):288-95. doi: 10.1159/000057338.
8
Formation of [17-2H]androsta-5,16-dien-3beta-ol from [17,21,21,21]pregnenolone by the microsomal fraction of boar testis.公猪睾丸微粒体部分由[17,21,21,21]孕烯醇酮形成[17-2H]雄甾-5,16-二烯-3β-醇。
Biochim Biophys Acta. 1976 Dec 20;450(3):441-9.
9
Nongenomic actions of neurosteroid pregnenolone and its metabolites.神经甾体孕烯醇酮及其代谢产物的非基因组作用。
Steroids. 2016 Jul;111:54-59. doi: 10.1016/j.steroids.2016.01.017. Epub 2016 Feb 1.
10
The Knoevenagel reactions of pregnenolone with cyanomethylene reagents: synthesis of thiophene, thieno[2,3-b]pyridine, thieno[3,2-d]isoxazole derivatives of pregnenolone and their in vitro cytotoxicity towards tumor and normal cell lines. pregnenolone 与氰基亚甲基试剂的 Knoevenagel 反应：孕烯醇酮的噻吩、噻吩并[2,3-b]吡啶、噻吩并[3,2-d]异恶唑衍生物的合成及其对肿瘤和正常细胞系的体外细胞毒性。
Steroids. 2013 Dec 11;78(12-13):1209-19. doi: 10.1016/j.steroids.2013.08.007. Epub 2013 Sep 5.

引用本文的文献

1
Pregnenolone Reduces L-Dopa-Induced Dyskinesias in Female Parkinsonian Monkeys.孕烯醇酮可减轻雌性帕金森病猴的左旋多巴诱发的异动症。
Mov Disord. 2025 Sep;40(9):1996-2001. doi: 10.1002/mds.30280. Epub 2025 Jul 5.
2
The role of genetic polymorphisms in the sulfation of pregnenolone by human cytosolic sulfotransferase SULT2B1a.遗传多态性在人胞质磺基转移酶 SULT2B1a 对孕烯醇酮磺化中的作用。
Sci Rep. 2024 Apr 5;14(1):8050. doi: 10.1038/s41598-024-56303-y.
3
The results of a unique dietary supplement (nutraceutical formulation) used to treat the symptoms of long-haul COVID.
一种用于治疗长期新冠症状的独特膳食补充剂（营养制剂）的结果。
Front Nutr. 2022 Oct 25;9:1034169. doi: 10.3389/fnut.2022.1034169. eCollection 2022.
4
Metabolomics analysis of post-traumatic stress disorder symptoms in World Trade Center responders.创伤后应激障碍症状的代谢组学分析在世界贸易中心的响应者。
Transl Psychiatry. 2022 Apr 28;12(1):174. doi: 10.1038/s41398-022-01940-y.
5
Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting.孕烯醇酮和孕烯醇酮甲醚对抑郁症和CDKL5缺乏症的治疗潜力：聚焦于微管靶向
J Neuroendocrinol. 2022 Feb;34(2):e13033. doi: 10.1111/jne.13033. Epub 2021 Sep 8.
6
Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss.孕烯醇酮抑制破骨细胞分化，保护免受脂多糖诱导的炎性骨破坏和卵巢切除诱导的骨质流失。
Front Pharmacol. 2020 Mar 27;11:360. doi: 10.3389/fphar.2020.00360. eCollection 2020.
7
The neurosteroid pregnenolone promotes degradation of key proteins in the innate immune signaling to suppress inflammation.神经甾体孕烯醇酮促进先天免疫信号中关键蛋白的降解，从而抑制炎症。
J Biol Chem. 2019 Mar 22;294(12):4596-4607. doi: 10.1074/jbc.RA118.005543. Epub 2019 Jan 15.
8
Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.以神经甾体孕烯醇酮为靶点治疗精神分裂症认知和阴性症状的概念验证试验。
Neuropsychopharmacology. 2009 Jul;34(8):1885-903. doi: 10.1038/npp.2009.26. Epub 2009 Apr 1.
9
Clinical assessment of rapidly acting agents in rheumatoid arthritis.类风湿关节炎速效药物的临床评估
Br Med J. 1950 Oct 7;2(4683):810-3. doi: 10.1136/bmj.2.4683.810.
10
Key role for pregnenolone in combination therapy that promotes recovery after spinal cord injury.孕烯醇酮在促进脊髓损伤后恢复的联合治疗中起关键作用。
Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12308-12. doi: 10.1073/pnas.91.25.12308.