Devgun M S, Dhillon H S
Department of Biochemistry, Law Hospital, Carluke.
J Clin Pathol. 1992 Feb;45(2):110-3. doi: 10.1136/jcp.45.2.110.
To show the extent of diurnal variations in serum urate concentration and the possible consequences on the clinical interpretation.
Nineteen controls and 40 patients took part in this study. Preliminary investigations on selected subjects provided blood samples at regular intervals between the hours of 0800 and 2300 hours. From these observations the timing of venepuncture for the remaining subjects was chosen at 0800-0900 hours, with a second sample taken between 1700 and 1800 hours. Analytical quality was monitored using quality control procedures and all samples were analysed in a single batch to minimise errors.
All subjects, except some hypertensive elderly women, showed a diurnal rhythm. The mean serum urate value between 0800-0900 hours was higher than that observed between 1700-1800 hours. A decrease of up to 30% was observed in a group of diabetic patients. Nine subjects in the study had hyperuricaemia in the morning, but only six in the afternoon, indicating the requirement of a reference interval that takes account of diurnal variations.
When studying the temporal relation for the medical importance, or when attempting to interpret the serum urate concentration, it is important to consider the diurnal rhythms of this analyte.
展示血清尿酸盐浓度的昼夜变化程度以及对临床解读可能产生的影响。
19名对照组人员和40名患者参与了本研究。对选定受试者进行初步调查，在08:00至23:00之间定期采集血样。根据这些观察结果，其余受试者的静脉穿刺时间选择在08:00 - 09:00，在17:00至18:00之间采集第二份样本。使用质量控制程序监测分析质量，所有样本均在一批中进行分析以尽量减少误差。
除一些老年高血压女性外，所有受试者均表现出昼夜节律。08:00 - 09:00之间的平均血清尿酸值高于17:00至18:00之间观察到的值。一组糖尿病患者中观察到高达30%的下降。研究中有9名受试者早晨血尿酸过高，但下午只有6名，这表明需要一个考虑昼夜变化的参考区间。
在研究医学重要性的时间关系或试图解读血清尿酸盐浓度时，考虑该分析物的昼夜节律很重要。
