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鼻脑型毛霉菌病:一例罕见病例报告

Rhinocerebral mucormycosis: an unusual case presentation.

作者信息

Bhattacharyya A K, Deshpande A R, Nayak S R, Kirtane M V, Ingle M V, Vora I M

机构信息

Department of Otorhinolaryngology, K.E.M. Hospital, Parel, Bombay, India.

出版信息

J Laryngol Otol. 1992 Jan;106(1):48-9. doi: 10.1017/s0022215100118584.

Abstract

Rhinocerebral mucormycosis is a rapidly fatal fungal disease which involves the nose, paranasal sinuses, orbit and central nervous system. The fungal infection is usually secondary to immunosuppression, diabetic acidosis, or antibiotic, steroid or cytotoxic therapy. It can also occur in patients suffering from burns, malignancy and haematological disorders. Current treatment consists of correction of the underlying disorder, repeated debridement of the wound in combination with intravenous amphotericin B. This paper describes our experience with a case of rhinocerebral mucormycosis. This is an unusual case in which mucormycosis was seen in a young female where no underlying cause was found. She responded to surgical debridement in combination with intravenous amphotericin B.

摘要

鼻脑型毛霉菌病是一种迅速致命的真菌病,累及鼻子、鼻窦、眼眶和中枢神经系统。真菌感染通常继发于免疫抑制、糖尿病酸中毒或抗生素、类固醇或细胞毒性治疗。它也可发生于烧伤、恶性肿瘤和血液系统疾病患者。目前的治疗方法包括纠正潜在疾病、反复清创伤口并联合静脉注射两性霉素B。本文描述了我们治疗一例鼻脑型毛霉菌病的经验。这是一例不寻常的病例,在一名年轻女性中发现了毛霉菌病,且未发现潜在病因。她对手术清创联合静脉注射两性霉素B有反应。

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