Ercan Ibrahim, Cakir Burak Omür, Civelek Senol, Turgut Suat
Department of Otolaryngology, Sişli Etfal Training Hospital, Istanbul, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2005;15(1-2):40-4.
Rhinocerebral mucormycosis is an aggressive fungal disease that involves the nose, paranasal sinuses, orbit and central nervous system. It may rapidly be fatal. This infection usually occurs secondary to immune suppression, diabetic ketoacidosis, and prolonged use of antibiotics, steroids, and cytotoxic drugs. Management of the condition consists of treatment of the underlying disease and surgical debridement combined with intravenous amphotericin B. This paper presents two patients with rhinocerebral mucormycosis, both suffering from diabetes. Complete recovery was achieved in one patient with surgical debridement of necrotic tissue combined with systemic antifungal treatment, whereas in the other, the disease was complicated with subarachnoid hemorrhage and the patient died on the third day of treatment.
鼻脑型毛霉菌病是一种侵袭性真菌疾病，累及鼻子、鼻窦、眼眶和中枢神经系统。它可能迅速致命。这种感染通常继发于免疫抑制、糖尿病酮症酸中毒以及长期使用抗生素、类固醇和细胞毒性药物。该病症的治疗包括治疗基础疾病、手术清创并联合静脉注射两性霉素B。本文介绍了两名患有鼻脑型毛霉菌病的患者，两人均患有糖尿病。其中一名患者通过对坏死组织进行手术清创并结合全身抗真菌治疗实现了完全康复，而另一名患者则并发蛛网膜下腔出血，在治疗第三天死亡。
