干扰素α诱导C3H/OuJ（Lpsn）和C3H/HeJ（Lpsd）巨噬细胞中FcγR特异性mRNA表达以及同型特异性、FcγR介导的吞噬作用的变化。
Interferon alpha-induced changes in Fc gamma R-specific mRNA expression and isotype-specific, Fc gamma R-mediated phagocytosis in C3H/OuJ (Lpsn) and C3H/HeJ (Lpsd) macrophages.
作者信息
Fultz M J, Vogel S N
机构信息
Department of Microbiology, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814.
出版信息
J Leukoc Biol. 1992 Mar;51(3):300-4. doi: 10.1002/jlb.51.3.300.
PMID:1541912
Abstract
Peritoneal exudate macrophages from C3H/OuJ (Lpsn) and C3H/HeJ (Lpsd) mice were treated with interferon alpha (IFN-alpha), and isotype-specific phagocytosis and gene expression were measured. IFN-alpha selectively augments phagocytosis of IgG2a, with a highly significant induction of Fc gamma RI mRNA expression, while parallel Fc gamma RIII alpha measurements show a relatively small increase.
摘要
用干扰素α（IFN-α）处理来自C3H/OuJ（Lpsn）和C3H/HeJ（Lpsd）小鼠的腹腔渗出巨噬细胞，并检测同型特异性吞噬作用和基因表达。IFN-α选择性增强IgG2a的吞噬作用，伴随FcγRI mRNA表达的高度显著诱导，而平行的FcγRIIIα检测显示增加相对较小。
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