糖尿病患者的胆囊容积与排空：神经病变和肥胖的作用

Gallbladder volume and emptying in diabetics: the role of neuropathy and obesity.

作者信息

Palasciano G, Portincasa P, Belfiore A, Baldassarre G, Cignarelli M, Paternostro A, Albano O, Giorgino R

机构信息

Institute of Clinica Medica I, University of Bari, Italy.

出版信息

J Intern Med. 1992 Feb;231(2):123-7. doi: 10.1111/j.1365-2796.1992.tb00512.x.

DOI:10.1111/j.1365-2796.1992.tb00512.x

PMID:1541933

Abstract

Gallbladder (GB) volume was monitored by real-time sonography in diabetics (n = 21) and healthy volunteers (n = 55) after a test meal. Seventeen controls and seven diabetics were obese; six patients had both autonomous and somatic neuropathy, and four had somatic neuropathy. Fasting GB volume was similar in controls and diabetics with and without autonomic neuropathy; it was correlated with body mass index (controls, r = 0.43, P less than 0.002; diabetics, r = 0.46, P less than 0.04), and was increased in obese subjects. Post-prandial GB emptying was decreased in diabetics. Those with autonomous neuropathy exhibited larger residual volumes than controls (P less than 0.03). Post-prandial GB emptying was slower and less complete in (non-diabetic) obese subjects and deteriorated further in diabetic obese subjects. GB fasting tone was normal, but GB kinetics were impaired in diabetics; obesity and autonomous neuropathy were correlated with GB hypomotility.

摘要

在进行试餐之后，通过实时超声检查监测糖尿病患者（n = 21）和健康志愿者（n = 55）的胆囊（GB）容积。17名对照者和7名糖尿病患者肥胖；6例患者同时患有自主神经病变和躯体神经病变，4例患有躯体神经病变。无论有无自主神经病变，糖尿病患者与对照者的空腹胆囊容积相似；其与体重指数相关（对照者，r = 0.43，P<0.002；糖尿病患者，r = 0.46，P<0.04），且在肥胖受试者中升高。糖尿病患者餐后胆囊排空减少。患有自主神经病变的患者比对照者表现出更大的残余容积（P<0.03）。（非糖尿病）肥胖受试者餐后胆囊排空更慢且更不完全，而糖尿病肥胖受试者的情况则更糟。胆囊空腹张力正常，但糖尿病患者的胆囊动力学受损；肥胖和自主神经病变与胆囊运动功能减退相关。