MacLEOD C M, KRAUS M R
J Exp Med. 1950 Jul 1;92(1):1-9. doi: 10.1084/jem.92.1.1.
The amount of capsular polysaccharide formed in vitro by strains of pneumococcus types II, III, and VII of different virulence for mice has been measured by quantitative precipitin reactions. The quantity produced by strains of high virulence was greater for all three types than that formed by moderately virulent or avirulent strains. It is suggested that an important factor concerned in variations of virulence of pneumococci for mice is the genetic apparatus that controls the amount of SSS synthesized by the cells.
通过定量沉淀反应测定了对小鼠具有不同毒力的Ⅱ型、Ⅲ型和Ⅶ型肺炎球菌菌株在体外形成的荚膜多糖量。对于所有这三种类型,高毒力菌株产生的量都比中等毒力或无毒力菌株形成的量要多。有人提出,肺炎球菌对小鼠毒力变化的一个重要因素是控制细胞合成SSS量的遗传机制。