Bornstein D L, Schiffman G, Bernheimer H P, Austrian R
J Exp Med. 1968 Dec 1;128(6):1385-400. doi: 10.1084/jem.128.6.1385.
Capsulated mutants of pneumococcus producing a capsule of soluble polysaccharide related immunologically to the C or cell wall polysaccharide of pneumococcus have been isolated from several noncapsulated variants of this organism. The capsular material of these strains reacts with antisera both to homologous strains and to noncapsulated strains of pneumococcus and with human C-reactive protein. C-reactive protein has been shown to give a positive capsular precipitin or Quellung reaction with C(s) pneumococcal variants and to agglutinate them. The genetic locus which determines the production of C(s) polysaccharide is situated in a region of the pneumococcal chromosome distinct from that controlling normal capsular polysaccharide synthesis. Binary and ternary capsulated pneumococci, one of the capsular components of which is C(s) polysaccharide, have been isolated following DNA-mediated transformation.
已从肺炎球菌的几种无荚膜变种中分离出产生与肺炎球菌的C或细胞壁多糖具有免疫相关性的可溶性多糖荚膜的肺炎球菌荚膜突变体。这些菌株的荚膜物质与同源菌株和肺炎球菌无荚膜菌株的抗血清以及与人类C反应蛋白发生反应。已证明C反应蛋白与C（s）肺炎球菌变种产生阳性荚膜沉淀素或荚膜肿胀反应并使其凝集。决定C（s）多糖产生的基因座位于肺炎球菌染色体中与控制正常荚膜多糖合成的区域不同的区域。在DNA介导的转化后，已分离出二元和三元荚膜肺炎球菌，其中一种荚膜成分是C（s）多糖。
