兔体内的自体抗变型免疫反应。

Autologous anti-metatype immune response in rabbits.

作者信息

Voss E W, Moore J K, Weidner-McGufficke K M, Denzin L K, Bedzyk W D, Voss V H

机构信息

Department of Microbiology, University of Illinois, Urbana 61801.

出版信息

Mol Immunol. 1992 Feb;29(2):241-9. doi: 10.1016/0161-5890(92)90105-7.

DOI:10.1016/0161-5890(92)90105-7

PMID:1542300

Abstract

Rabbits hyperimmunized with fluorescyl-conjugated KLH exhibited bound ligand associated with a high affinity circulating IgG anti-fluorescein population. After cessation of immunogen administration the liganded complexes were eventually spontaneously cleared from the circulation. Individual rabbits synthesized autologous anti-metatype antibodies specific for ligand-antibody complexes. Autologous anti-metatype antibodies reacted optimally with autologous liganded anti-fluorescein antibodies. However, cross reactivity was noted with allogenic rabbit liganded antibodies from three affinity-purified pools. An autologous anti-metatype response, reminiscent of autoanti-idiotype responses, has important implications concerning in vivo clearance of antigen-antibody complexes and may serve as a model to study immune complex diseases.

摘要

用荧光素共轭钥孔戚血蓝蛋白（KLH）进行超免疫的兔子表现出与高亲和力循环IgG抗荧光素群体相关的结合配体。停止给予免疫原后，配体化复合物最终从循环中自发清除。个体兔子合成了针对配体 - 抗体复合物的自体抗独特型抗体。自体抗独特型抗体与自体配体化抗荧光素抗体反应最佳。然而，观察到与来自三个亲和纯化库的同种异体兔子配体化抗体有交叉反应。一种自体抗独特型反应，让人联想到自身抗独特型反应，对抗抗原 - 抗体复合物的体内清除具有重要意义，并且可以作为研究免疫复合物疾病的模型。