Fewell J E
Department of Obstetrics and Gynaecology, University of Calgary, Alberta, Canada.
Pediatr Res. 1992 Feb;31(2):107-11. doi: 10.1203/00006450-199202000-00003.
Experiments were done on 13 young lambs to determine if carotid denervation influences the cardiovascular and metabolic responses to i.v. administration of bacterial pyrogen [Salmonella abortus equi (SAE) 0.3 micrograms]. Each lamb was anesthetized with halothane and prepared for measurements of cardiac output, arterial and mixed venous oxygen saturations, and body core temperature. No sooner than 3 d after surgery, measurements were made during a control period and at 10-min intervals for 120 min after i.v. administration of SAE in seven carotid-intact lambs and six carotid-denervated lambs. Administration of SAE produced a short-lived fever of about 1 degrees C in the carotid-intact lambs, whereas no change in body core temperature was observed in the carotid-denervated lambs. In carotid-intact lambs, the rise in body core temperature began approximately 40 min after administration of SAE and continued for approximately 50 min. This rise in body core temperature was preceded by the onset of shivering and an increase in total body oxygen consumption. Carotid denervation produced changes in some of the cardiovascular variables during the control period (i.e. arterial oxygen content, cardiac index, heart rate, and pulmonary blood pressure); however, there were no additional significant changes in any of the metabolic or cardiovascular variables after administration of SAE. The mechanism of these unexpected findings remains to be determined.
对13只幼羊进行了实验，以确定颈动脉去神经支配是否会影响静脉注射细菌热原[马流产沙门氏菌（SAE）0.3微克]后的心血管和代谢反应。每只羊用氟烷麻醉，并准备好测量心输出量、动脉血氧饱和度和混合静脉血氧饱和度以及体核温度。术后不少于3天，在7只颈动脉完整的羊和6只颈动脉去神经支配的羊中，在对照期以及静脉注射SAE后120分钟内每隔10分钟进行一次测量。静脉注射SAE在颈动脉完整的羊中引起了约1℃的短暂发热，而在颈动脉去神经支配的羊中未观察到体核温度变化。在颈动脉完整的羊中，体核温度在注射SAE后约40分钟开始升高，并持续约50分钟。在体核温度升高之前出现了寒颤，全身氧耗增加。颈动脉去神经支配在对照期引起了一些心血管变量的变化（即动脉血氧含量、心脏指数、心率和肺动脉压）；然而，静脉注射SAE后，任何代谢或心血管变量均未出现额外的显著变化。这些意外发现的机制尚待确定。
