达尔马提亚猎犬尿酸排泄的肾脏机制。
The renal mechanism for urate excretion in the Dalmatian coach-hound.
作者信息
WOLFSON W Q, COHN C, SHORE C
出版信息
J Exp Med. 1950 Aug;92(2):121-8. doi: 10.1084/jem.92.2.121.
Abstract
- The renal mechanism for urate excretion in the Dalmatian dog resembles that in birds. Urate is cleared at a rate considerably greater than the glomerular filtration rate, indicating that its excretion is the result of both glomerular filtration and active tubular secretion. The basic physiological mechanisms involved in the anomalous purine metabolism of the Dalmatian are indicated and their possible biological significance briefly discussed. 2. A new enzymatic method for the direct estimation of true urate in biological fluids is described, which does not require the estimation of total urate and urate chromogen, followed by the calculation of true urate as a difference.
摘要
- 达尔马提亚犬尿酸排泄的肾脏机制与鸟类相似。尿酸清除率远高于肾小球滤过率，这表明其排泄是肾小球滤过和肾小管主动分泌共同作用的结果。文中指出了达尔马提亚犬异常嘌呤代谢所涉及的基本生理机制，并简要讨论了其可能的生物学意义。2. 本文描述了一种直接测定生物体液中真实尿酸的新酶法，该方法无需先测定总尿酸和尿酸色原，再通过计算两者差值来得出真实尿酸。
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本文引用的文献
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Hypouricemia: with evidence for tubular elimination of uric acid.低尿酸血症：有肾小管排泄尿酸的证据。
J Lab Clin Med. 1950 Jun;35(6):865-8.
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