Ferrante P, Petronzelli F, Mariani P, Bonamico M, Mazzilli M C
Department of Experimental Medicine, University La Sapienza, Rome, Italy.
Tissue Antigens. 1992 Jan;39(1):38-9. doi: 10.1111/j.1399-0039.1992.tb02155.x.
Oligotyping for HLA-DRB1, DQA1 and DQB1 specificities has been performed on PCR-amplified DNA from 55 Italian celiac children, living in Rome, and 50 blood donors. 52.6% of CD patients were DR3;DQA10501;DQB10201-positive versus 14% of controls (RR = 6.85) and 34.5% were DR5,7;DQA1DQB10201-positive versus 2% of controls (RR = 25.86). 7 patients (12.7%) were negative for the DQA10501/B10201 dimer: 3 of them were DR4 (5.4%) and the others typed as DR1,5; 1,7; 5,7 and w6,7. No patient was negative for both DQA10501 and DQB10201 alleles.
已对来自55名居住在罗马的意大利乳糜泻儿童和50名献血者的PCR扩增DNA进行了HLA - DRB1、DQA1和DQB1特异性寡核苷酸分型。52.6%的乳糜泻患者为DR3;DQA10501;DQB10201阳性，而对照组为14%（相对风险率RR = 6.85）；34.5%为DR5,7;DQA1DQB10201阳性，而对照组为2%（RR = 25.86）。7名患者（12.7%）DQA10501/B10201二聚体呈阴性：其中3名是DR4（5.4%），其他分型为DR1,5；1,7；5,7和w6,7。没有患者DQA10501和DQB10201等位基因均为阴性。
