罗马尼亚人群中人类白细胞抗原的多态性。

Polymorphism of HLA in the Romanian population.

作者信息

Reed E, Ho E, Lupu F, McManus P, Vasilescu R, Foca-Rodi A, Suciu-Foca N

机构信息

Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York.

出版信息

Tissue Antigens. 1992 Jan;39(1):8-13. doi: 10.1111/j.1399-0039.1992.tb02148.x.

DOI:10.1111/j.1399-0039.1992.tb02148.x

PMID:1542880

Abstract

We have investigated the HLA-class I and class II polymorphism in a population of 83 Romanians using conventional serology together with PCR amplification and oligonucleotide typing of HLA-class II genes. Romanians show a higher frequency of HLA-A11, B13, B18, B37, B39, B51 and DR2 than other European populations. HLA-DRB11501 and 1601 account for the high frequency of the serologic specificity DR2. In Romanians, HLA-DR2 is in linkage disequilibrium with HLA-B18 and HLA-Bw52 rather than with HLA-B7 as in the case in other Europeans. Unexpected HLA-DR2 haplotypes include HLA-DRB11502, DQA10102, DQB10601; HLA-DRB11602, DQA10102, DQB10502. Other unusual haplotypes include HLA-DRB10405, DQA103, DQB10302; HLA-DRB11305, DQA10103, DQB10603; and HLA-DRB11405, DQA10101, DQB105032. Analysis of the genetic distance between Romanians and other Europeans who have been studied serologically are consistent with the hypothesis that Romanians descend from Roman ancestors who colonized Dacia between the 1st century B.C. and 1st century A.D.

摘要

我们运用传统血清学方法，结合 HLA - II 类基因的聚合酶链反应（PCR）扩增及寡核苷酸分型技术，对 83 名罗马尼亚人群的 HLA - I 类和 II 类多态性进行了研究。罗马尼亚人 HLA - A11、B13、B18、B37、B39、B51 和 DR2 的频率高于其他欧洲人群。HLA - DRB11501 和 1601 导致了血清学特异性 DR2 的高频率出现。在罗马尼亚人中，HLA - DR2 与 HLA - B18 和 HLA - Bw52 处于连锁不平衡状态，而非像其他欧洲人那样与 HLA - B7 处于连锁不平衡。意外的 HLA - DR2 单倍型包括 HLA - DRB11502、DQA10102、DQB10601；HLA - DRB11602、DQA10102、DQB10502。其他不寻常的单倍型包括 HLA - DRB10405、DQA103、DQB10302；HLA - DRB11305、DQA10103、DQB10603；以及 HLA - DRB11405、DQA10101、DQB105032。对罗马尼亚人与其他已进行血清学研究的欧洲人之间遗传距离的分析，与罗马尼亚人源自公元前 1 世纪至公元 1 世纪在达契亚殖民的罗马祖先这一假说相符。