罗马尼亚人群中HLA等位基因的频率。
The frequency of HLA alleles in the Romanian population.
作者信息
Constantinescu Ileana, Boșcaiu Voicu, Cianga Petru, Dinu Andrei-Antoniu, Gai Elena, Melinte Mihaela, Moise Ana
机构信息
Department of Transplant Immunology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Centre for Immunogenetics, Fundeni Clinical Institute, Bucharest, Romania.
出版信息
Immunogenetics. 2016 Mar;68(3):167-78. doi: 10.1007/s00251-015-0891-9. Epub 2015 Dec 28.
Knowledge of human leukocyte antigen (HLA) allele frequencies is essential for bone marrow and kidney donor searches. The Romanian Caucasian population is heterogeneous and information on HLA polymorphism has not been well studied. We characterized the HLA genetic profile and allele frequencies of regional populations in Romania. HLA-A, B and DRB1 alleles were examined in 8252 individuals, belonging to the four main regions of Romania. The most common alleles found in the Romanian population are the following: HLA-A01, A02, A03, A11, A24; HLA-B18, B35, B44, B51 and HLA-DRB101, DRB103, DRB107, DRB111, DRB113, DRB115, DRB116. More than half of the alleles are non-homogeneously spread in Romania. These results provide a starting point for future analyses of genetic heterogeneity in Romania.
了解人类白细胞抗原（HLA）等位基因频率对于骨髓和肾脏供体搜索至关重要。罗马尼亚高加索人群具有异质性，关于HLA多态性的信息尚未得到充分研究。我们对罗马尼亚地区人群的HLA基因谱和等位基因频率进行了特征分析。在属于罗马尼亚四个主要地区的8252名个体中检测了HLA-A、B和DRB1等位基因。在罗马尼亚人群中发现的最常见等位基因如下：HLA-A01、A02、A03、A11、A24；HLA-B18、B35、B44、B51以及HLA-DRB101、DRB103、DRB107、DRB111、DRB113、DRB115、DRB116。超过一半的等位基因在罗马尼亚分布不均一。这些结果为未来罗马尼亚遗传异质性分析提供了一个起点。
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