Nakane M, Teraoka A, Asato R, Tamura A
Department of Neurosurgery, Tokyo Metropolitan Bokuto Hospital, Japan.
Stroke. 1992 Mar;23(3):328-32. doi: 10.1161/01.str.23.3.328.
In rats, degeneration of the ipsilateral substantia nigra occurs a few weeks after occlusion of the middle cerebral artery. The aim of this study was to clarify whether similar change is observed in stroke patients.
Eighteen patients with striatal infarction and six patients with cortical infarction in the territory of the middle cerebral artery were examined by means of sequential magnetic resonance imaging.
In all patients with striatal infarction, T2-weighted images revealed a high-signal-intensity spot in the ipsilateral substantia nigra. Changes in the ipsilateral substantial nigra appeared at day 14 after stroke on average and then became less intense and smaller a few months after the stroke. By contrast, we observed no nigral changes in any patient with cortical infarction.
The degenerative change in the ipsilateral substantia nigra initially found in the rat model similarly occurred in patients with striatal infarction. This remote change in the substantia nigra may represent magnetic resonance imaging detection of neuropathologic changes in this region through the striatonigral pathway.
在大鼠中，大脑中动脉闭塞几周后同侧黑质会发生退变。本研究的目的是明确中风患者是否会出现类似变化。
通过连续磁共振成像对18例大脑中动脉供血区纹状体梗死患者和6例皮质梗死患者进行检查。
在所有纹状体梗死患者中，T2加权图像显示同侧黑质有高信号强度斑点。同侧黑质的变化平均在中风后第14天出现，然后在中风后几个月变得不那么明显且范围缩小。相比之下，我们在任何皮质梗死患者中均未观察到黑质变化。
最初在大鼠模型中发现的同侧黑质退变变化同样发生在纹状体梗死患者中。黑质的这种远隔变化可能代表通过纹状体黑质通路对该区域神经病理变化的磁共振成像检测。
