Russell A S, Chalmers I M, Percy J S, Lentle B C
Arthritis Rheum. 1979 Mar;22(3):215-8. doi: 10.1002/art.1780220302.
Nineteen patients with Paget's disease of bone were studied 7 months to 5 years after therapy with mithramycin in a dose averaging 11.5 microgram/kg body weight daily for 10 days. Thirteen patients, including 3 with the longest followup intervals, remained free of pain. Objective measures of disease activity (serum alkaline phosphatase level and 99mtechnetium pyrophosphate bone scan) were less favorable. There was no evidence of long term toxicity.
对19例骨佩吉特病患者进行了研究，这些患者在接受光辉霉素治疗后7个月至5年，治疗剂量平均为每日11.5微克/千克体重，持续10天。13例患者，包括3例随访间隔最长的患者，仍无疼痛。疾病活动的客观指标（血清碱性磷酸酶水平和99m锝焦磷酸盐骨扫描）不太理想。没有长期毒性的证据。
