Ryan W G
Clin Orthop Relat Res. 1977(127):106-10.
The hypothesis that Paget's disease of bone is a low grade neoplastic process led us to use the cytotoxic antibiotic mithramycin in its treatment. The dramatic effects observed on the serum calcium and alkaline phosphatase, and urinary hydroxyproline are compatible with the concept that mithramycin is primarily toxic to osteoclasts. Subjective and objective clinical effects establish this agent as useful in the treatment of Paget's disease despite its observed toxicity to other organ systems.
认为骨Paget病是一种低度肿瘤性病变的假说，促使我们使用细胞毒性抗生素光辉霉素对其进行治疗。观察到的血清钙、碱性磷酸酶及尿羟脯氨酸水平的显著变化，与光辉霉素主要对破骨细胞有毒性这一概念相符。尽管观察到光辉霉素对其他器官系统有毒性，但主观和客观的临床疗效表明该药物对治疗Paget病有效。
