源自肉毒梭菌E型（白鲸菌株）和丁酸梭菌（ATCC 43181菌株和ATCC 43755菌株）的肉毒杆菌神经毒素E的序列。
Sequences of the botulinal neurotoxin E derived from Clostridium botulinum type E (strain Beluga) and Clostridium butyricum (strains ATCC 43181 and ATCC 43755).
作者信息
Poulet S, Hauser D, Quanz M, Niemann H, Popoff M R
机构信息
Unité des Antigènes Bactériens, Institut Pasteur, Paris, France.
出版信息
Biochem Biophys Res Commun. 1992 Feb 28;183(1):107-13. doi: 10.1016/0006-291x(92)91615-w.
Recently, it has been shown that two Clostridium butyricum strains (ATCC 43181 and ATCC 43755), isolated from cases of infant botulism, produce a botulinal neurotoxin type E (BoNT/E). Here we have determined the nucleotide sequences of the BoNT/E genes of these two C. butyricum strains and from C. botulinum E strain Beluga. We show that the sequences of the BoNT/E genes from the two C. butyricum strains are identical and differ in only 64 positions resulting in 39 amino acid changes (97% identity at the amino acid level) from that derived from C. botulinum. Our data suggest a transfer of the BoNT/E gene from C. botulinum to the originally nontoxigenic C. butyricum strains.
最近研究表明，从婴儿肉毒中毒病例中分离出的两株丁酸梭菌（ATCC 43181和ATCC 43755）能产生E型肉毒杆菌神经毒素（BoNT/E）。在此，我们测定了这两株丁酸梭菌以及肉毒杆菌E型菌株白鲸的BoNT/E基因的核苷酸序列。我们发现，两株丁酸梭菌的BoNT/E基因序列相同，与肉毒杆菌的序列相比，仅有64个位置不同，导致39个氨基酸发生变化（氨基酸水平上的同一性为97%）。我们的数据表明，BoNT/E基因从肉毒杆菌转移到了原本无毒的丁酸梭菌菌株中。
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