Steinbach E, Karger B, Hildmann H
Arzt für Hals-, Nasen- und Ohrenheilkunde, Reutlingen.
Laryngorhinootologie. 1992 Jan;71(1):11-4. doi: 10.1055/s-2007-997236.
30 autogenic and allogenic (homologous) cartilage grafts removed from the middle ear after an average time of 9 years and a maximal time of 25 years were studied by light microscopy. Half of the grafts showed signs of cellular vitality. Degeneration and avital cells are predominant in all grafts. Persisting residual vitality does not influence resorption and matrix necrosis in other areas of the graft. More than two thirds show structural changes by cellular resorption, infraction and vascularisation. These changes appear mainly independent of the time elapsed after transplantation. 5 grafts show bone new formation. Circumscript necrosis of the cartilage matrix was seen in 12 grafts. The study indicates that in comparison to ossicles or alloplastic material cartilage is less advisable to be used for the reconstruction of the ossicular chain due to the unpredictable degradation and loss of form stability.
对30块自体和同种异体（同源）软骨移植物进行了光镜研究，这些移植物取自中耳，平均时间为9年，最长时间为25年。一半的移植物显示出细胞活力的迹象。所有移植物中退化和无活力细胞占主导。持续的残余活力并不影响移植物其他区域的吸收和基质坏死。超过三分之二的移植物通过细胞吸收、破裂和血管化出现结构变化。这些变化主要与移植后经过的时间无关。5块移植物出现新骨形成。12块移植物中可见软骨基质的局灶性坏死。该研究表明，与听小骨或异体材料相比，由于软骨降解不可预测且形状稳定性丧失，因此不太建议用于听骨链重建。
