Hildmann H, Karger B, Steinbach E
Universitäts-HNO-Klinik Bochum.
Laryngorhinootologie. 1992 Jan;71(1):5-10.
In this study 130 ossicular middle ear transplants were studied. 33 remained in the middle ear for 10 years or longer, one for 21 years. The majority of the grafts show 5% to 40% bone new formation. Absence of vital bone or subtotal host bone replacement is exceptional. The amount of bone new formation appears independent the implantation time. 75% of the grafts show no bone resorption. In 15% sound transmitting might be impaired due to resorption. Grafts with a high degree of bone new formation show less resorption. 21% of the ossicles have signs of inflammation. Inflammation boosts bone turnover with resorption on one hand and new for resorption. Cholesteatoma is the main cause of resorption and inflammation. The critical phase for resorption of the graft are the first two to three years after transplantation. No considerable difference was found between autografts and allografts (homografts). Histological and metabolical properties of the ossicles seem to be responsible for the stability of the graft. Ossicular grafts have a good longterm stability which makes them very suitable for reconstruction of the ossicular chain.
在本研究中，对130例听骨链中耳移植进行了研究。33例在中耳留存10年或更长时间，1例留存21年。大多数移植物显示有5%至40%的新骨形成。无活性骨或宿主骨大部分被替代的情况极为罕见。新骨形成的量似乎与植入时间无关。75%的移植物未显示骨吸收。15%的移植物可能因吸收而导致传音功能受损。新骨形成程度高的移植物吸收较少。21%的听骨有炎症迹象。炎症一方面通过吸收促进骨转换，另一方面促进新骨形成以进行吸收。胆脂瘤是吸收和炎症的主要原因。移植物吸收的关键阶段是移植后的头两到三年。自体移植物和同种异体移植物（同种移植）之间未发现显著差异。听骨的组织学和代谢特性似乎决定了移植物的稳定性。听骨移植物具有良好的长期稳定性，这使其非常适合用于听骨链重建。
