一种定量检测血浆中5-氟尿嘧啶和5-氟脱氧尿苷水平的新方法的潜在临床应用
Potential clinical applications of a new method for quantitation of plasma levels of 5-fluorouracil and 5-fluorodeoxyuridine.
作者信息
Jones R A, Buckpitt A R, Londer H H, Myers C E, Chabner B A, Boyd M R
出版信息
Bull Cancer. 1979;66(1):75-8.
PMID:154353
Abstract
A new high-pressure liquid chromatographic method for the clinical assay of 5-fluorouracil and 5-fluoroudexyuridine has been developed. The sensitivity and specificity of the method equals that of gas chromatography/mass spectrometric methods. The practical value of the method has been demonstrated by its application in several preliminary clinical studies of 5-fluorouracil in which plasma levels of 10(-8)-10(-6)M were readily monitored.
摘要
已开发出一种用于临床测定5-氟尿嘧啶和5-氟脱氧尿苷的新型高效液相色谱法。该方法的灵敏度和特异性与气相色谱/质谱法相当。通过在5-氟尿嘧啶的几项初步临床研究中的应用，已证明了该方法的实用价值，在这些研究中可轻松监测到10^(-8)-10^(-6)M的血浆水平。
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