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美沙酮治疗项目结局的预测因素:HIV咨询与检测的影响

Predictors of outcome in methadone programs: effect of HIV counseling and testing.

作者信息

Farley T A, Cartter M L, Wassell J T, Hadler J L

机构信息

Division of Field Services, Centers for Disease Control, Atlanta, Georgia.

出版信息

AIDS. 1992 Jan;6(1):115-21. doi: 10.1097/00002030-199201000-00016.

DOI:10.1097/00002030-199201000-00016
PMID:1543554
Abstract

OBJECTIVE

To identify predictors of treatment outcomes in methadone maintenance programs and to determine whether HIV counseling and testing influenced these outcomes.

DESIGN

Retrospective record review.

SETTING

Four methadone maintenance programs in four cities in Connecticut, USA.

PARTICIPANTS

Five hundred and ninety-four clients, who began treatment over an 18-month period and for whom records were available, took part.

INTERVENTIONS

HIV counseling and testing.

MAIN OUTCOME MEASURES

Risk of treatment discontinuation and persistent in-treatment illicit drug use.

RESULTS

The most important predictor of treatment discontinuation and of persistent in-treatment illicit drug use was self-reported pre-treatment cocaine use. After controlling for this and demographic risk factors, clients who received initial HIV counseling, when compared with clients who did not, had a similar 12-month discontinuation risk (54 versus 59%; P = 0.08) but were less likely to show persistent illicit drug use (46 versus 53%; P = 0.01). Among counseled entrants who were tested for HIV antibodies, those receiving positive results had a 12-month discontinuation risk similar to those receiving negative results (50 versus 52%), but more often showed persistent illicit drug use (57 versus 44%), although this difference may have been due to chance (P = 0.28). The majority of clients who discontinued treatment did so because they were discharged for non-compliance with clinic rules, usually for failing to pay fees.

CONCLUSIONS

HIV counseling and testing do not have a substantial adverse effect on methadone treatment outcomes. In the clinics under study, failure to pay clinic fees was an important factor contributing to discontinuation of treatment.

摘要

目的

确定美沙酮维持治疗项目中治疗结果的预测因素,并确定HIV咨询与检测是否会影响这些结果。

设计

回顾性记录审查。

地点

美国康涅狄格州四个城市的四个美沙酮维持治疗项目。

参与者

594名在18个月期间开始治疗且有记录可查的患者参与了研究。

干预措施

HIV咨询与检测。

主要结局指标

治疗中断风险和治疗期间持续使用非法药物的情况。

结果

治疗中断和治疗期间持续使用非法药物的最重要预测因素是自我报告的治疗前可卡因使用情况。在控制了这一因素和人口统计学风险因素后,接受初始HIV咨询的患者与未接受咨询的患者相比,12个月的治疗中断风险相似(分别为54%和59%;P = 0.08),但持续使用非法药物的可能性较小(分别为46%和53%;P = 0.01)。在接受HIV抗体检测的咨询入组者中,检测结果呈阳性的患者12个月的治疗中断风险与检测结果呈阴性的患者相似(分别为50%和52%),但更常出现持续使用非法药物的情况(分别为57%和44%),尽管这种差异可能是偶然因素所致(P = 0.28)。大多数中断治疗的患者是因为未遵守诊所规定(通常是未支付费用)而被出院。

结论

HIV咨询与检测对美沙酮治疗结果没有实质性的不利影响。在所研究的诊所中,未支付诊所费用是导致治疗中断的一个重要因素。

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