钾对恒河猴通气的影响。

Effect of potassium on ventilation in the rhesus monkey.

作者信息

Paterson D J, Dorrington K L, Bergel D H, Kerr G, Miall R C, Stein J F, Nye P C

机构信息

University Laboratory of Physiology, Oxford.

出版信息

Exp Physiol. 1992 Jan;77(1):217-20. doi: 10.1113/expphysiol.1992.sp003577.

DOI:10.1113/expphysiol.1992.sp003577

PMID:1543587

Abstract

Increasing the concentration of arterial plasma K+ to 6-8 mM increased ventilation in two sedated analgesic-treated rhesus monkeys who had their end-tidal CO2 held constant during euoxia (arterial oxygen pressure, Pa,O2, ca 100 Torr) and hypoxia (Pa,O2, ca 40 Torr). During euoxia and hypoxia, hyperkalaemia increased ventilation up to 40 and 250%, respectively. This effect was reduced in euoxia and virtually abolished in hypoxia following an abrupt switch to 100% oxygen. Thus the ventilatory response of this primate to hyperkalaemia is at least as sensitive as that of the cat and if hypoxia is added the two stimuli generate a powerful drive to breathing.

摘要

在两只接受镇静镇痛治疗的恒河猴中，将动脉血浆钾离子浓度提高到6 - 8毫摩尔/升，在常氧（动脉血氧分压，Pa,O2，约100托）和低氧（Pa,O2，约40托）期间使呼气末二氧化碳保持恒定时，通气量增加。在常氧和低氧期间，高钾血症分别使通气量增加高达40%和250%。突然切换到100%氧气后，这种效应在常氧时减弱，在低氧时几乎消失。因此，这种灵长类动物对高钾血症的通气反应至少与猫一样敏感，并且如果加上低氧，这两种刺激会产生强大的呼吸驱动。