Paradies G, Ruggiero F M, Gadaleta M N, Quagliariello E
Department of Biochemistry and Molecular Biology, University of Bari, Italy.
Biochim Biophys Acta. 1992 Jan 31;1103(2):324-6. doi: 10.1016/0005-2736(92)90103-s.
The effect of aging and treatment with acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria was studied. It was found that the activity of the phosphate carrier was reduced by aging. Treatment of aged rats with acetyl-L-carnitine reversed this effect. The mitochondrial level of cardiolipin was decreased with aging. Treatment of aged rats with acetyl-L-carnitine restored the level of cardiolipin to that of young rats. It is proposed that acetyl-L-carnitine may restore the correct phospholipid composition (cardiolipin level) of the mitochondrial membrane, altered by aging, thereby restoring the activity of the phosphate carrier.
研究了衰老以及用乙酰-L-肉碱处理对大鼠心脏线粒体中磷酸载体活性和磷脂组成的影响。发现衰老会降低磷酸载体的活性。用乙酰-L-肉碱处理老年大鼠可逆转这种效应。随着衰老，心磷脂的线粒体水平降低。用乙酰-L-肉碱处理老年大鼠可使心磷脂水平恢复到年轻大鼠的水平。有人提出，乙酰-L-肉碱可能恢复因衰老而改变的线粒体膜正确的磷脂组成（心磷脂水平），从而恢复磷酸载体的活性。
