Paradies G, Ruggiero F M, Petrosillo G, Gadaleta M N, Quagliariello E
Department of Biochemistry and Molecular Biology, University of Bari, Italy.
FEBS Lett. 1994 Aug 22;350(2-3):213-5. doi: 10.1016/0014-5793(94)00763-2.
The effect of aging and treatment with acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria was studied. It was found that the activity of both these mitochondrial protein systems was reduced (by around 30%) in aged animals. Treatment of aged rats with acetyl-L-carnitine almost completely reversed this effect. Changes in the mitochondrial cardiolipin content appear to be responsible for these effects of acetyl-L-carnitine.
研究了衰老以及用乙酰-L-肉碱处理对大鼠心脏线粒体中细胞色素氧化酶和腺嘌呤核苷酸转位酶活性的影响。结果发现，在老年动物中，这两种线粒体蛋白质系统的活性均降低（约30%）。用乙酰-L-肉碱处理老年大鼠几乎完全逆转了这种效应。线粒体心磷脂含量的变化似乎是乙酰-L-肉碱产生这些效应的原因。
